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The MTHFR enzyme is responsible for converting tetrahydrofolate into 5-methyltetrahydrofolate (5-MTHF), and reduced enzyme activity may influence methylation efficiency, particularly if riboflavin (vitamin B2) status is suboptimal
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While proper hydration is important, excessive water intake (more than 3-4 litres daily) without electrolyte replacement could potentially cause electrolyte imbalances
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