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Two scientists whose work at Massachusetts General Hospital decades ago led to the revolutionary weight-loss drugs now racking up billions in sales have won a Lasker Award, one of the most prestigious prizes in medicine

Indeed, a family of glucagon-related peptides exists, all of which are derived from differential processing of a common prohormone, proglucagon ( Interestingly, anglerfish islets were demonstrated to express two separate proglucagon peptides, meaning a hybrid approach was taken to identify cDNA encoding the 29 amino acid (aa), anglerfish glucagon ( Whilst work in anglerfish provided an excellent starting point, particularly in highlighting the presence of these carboxy glucagon-related peptides ( We now understand that proglucagon is expressed in both alpha-cells of the pancreatic islets ( Figure 1 )