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Description

This mechanism involves the conversion of Phosphatidylinositol-4,5-bisphosphate (PIP2) to Phosphatidylinositol-3,4,5-trisphosphate (PIP3), facilitating Akt activation by membrane translocation and phosphorylation by PIP3-dependent kinases

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The loss of this arousal response is a clear sign of HPA axis dysfunction, and an illustration of the fact that stress is poorly managed in PAIS

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