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When used as part of CagriSema, the dosing schedule looked like this in trials: Weeks 04: 0.25 mg cagrilintide + 0.25 mg semaglutide Weeks 48: 0.5 mg + 0.5 mg Weeks 812: 1 mg + 1 mg Weeks 1216: 1.7 mg + 1.7 mg Week 16 onward: 2.4 mg + 2.4 mg (full maintenance dose) Until the medication is approved and prescribing information is finalized, any dosing decisions would only happen through participation in a clinical trial or, eventually, under the guidance of a healthcare provider

Response: We appreciate the support from commenters regarding the modification to the High Priority Practices SAFER Guide measure that will require the use of the updated 2025 version of the High Priority Practices SAFER Guide

Using the acetate form would mean having to constantly reconstitute fresh batches to ensure consistent potency, introducing more steps and more room for error

Of 544 screened papers, the reviewers identified 36 studies meeting inclusion criteria 35 preclinical and one human study