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The first stage is Trem2-independent and involves a reduction in homeostatic microglia checkpoint genes such as Cx3cr1, P2ry12 , and P2ry13 , along with upregulation of genes including the Trem2-signaling adaptor Tyrobp, Apoe , and B2m

The clustering was guided by the Bayesian Information Criterion (BIC), selecting models with the highest BICs to evaluate performance and guide the clustering process

Reusing them can make injections more painful, increase the risk of irritation and affect how well the dose is delivered

AUTHORS Joseph Lee is a General Practitioner and doctoral researcher based at the Nuffield Department of Primary Care Health Sciences, University of Oxford