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On December 18, Eli Lilly announced that it had submitted a New Drug Application (NDA) for orforglipron to the U.S
Optogenetic activation of the neurons triggered immediate meal termination and reduced bout duration and frequency, while neural inhibition prolonged bout duration and increased food intake, showing that the neurons are necessary and sufficient for satiation
The gastric emptying effect is the most significant
The main hormonal alterations found in PCOS include increased luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio, hyperandrogenism, and insulin resistance, with consequent compensatory hyperinsulinemia, occasionally independent of body weight [2, 8]
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