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Moreover, studies suggest that dual and triple receptor agonists may have additional effects on histological NASH features vs high-dose GLP-1R agonists alone, and that these may be independent of changes in body weight [78]

Think about the people who navigate other major transformations well, the ones who finish a demanding training program, or a stretch of real therapeutic work, and come out the other side somewhere they actually meant to go

AstraZeneca's commercial obesity heritage is cotadutide (GLP-1/glucagon dual, divested) and its longer-term diabetes franchise (dapagliflozin and its combinations)