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The exact mechanism of the dysesthesia side effect is not known, but researchers hypothesize it may be due to the activation of the glucagon or GLP-1 receptors, as these receptors are expressed on central and peripheral nerves

doi: 10.2337/dc19-0749 23 ZinmanBBhosekarVBuschRHolstILudvikBThielkeDet al

110,111 Contrary to the classical gene silencing mechanism, research has shown that miRNAs can interact with 3-UTR to upregulate gene expression, indicating the complexity and diversity of miRNA regulatory mechanisms