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10.1371/journal.pone.0327135 148 MaT.HuangC.XuQ.YangY.LiuY.MengX.et al (2017)

These recent studies were able to elucidate increases in various functional metabolic modules, including diacylglycerol lipotoxicity (diacylglycerol-driven proinflammatory signaling) and ceramide-mediated lipotoxicity, membrane phospholipid remodeling (altered membrane lipid composition), mitochondrial redox dysfunction or oxidative balance, and ether-lipid and plasmalogen depletion (loss of protective antioxidant membrane lipids)

Bodies don't want to make their own hormones when receiving them externally

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