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In a study using high-fat diet mice treated with AAV-mediated follistatin gene therapy, follistatin overexpression demonstrated multifactorial effects, including increased muscle mass, improved metabolism, and browning of adipose tissue.[85] Exercise mimetics offer an alternative for individuals unable to engage in physical activity but who require its physiological benefits

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The findings indicated that patients on GLP-1RAs and/or DPP-4 inhibitors experienced better disease outcomes compared to those on different treatments, accompanied by an incidence rate ratio (IRR) of 0.52 (95% confidence interval: 0.420.65) [227]