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This corticosubcortical circuit is initially responsive to dopaminergic medications, particularly levodopa, which effectively control motor symptoms in the early stage of the disease 1,3,24

Although fatigue prevalence fluctuates concerning cirrhosis etiology, ranging from 44% in autoimmune liver disease to as high as 80% in primary biliary cholangitis (7), it is noteworthy that this symptom may not necessarily correlate with the severity of underlying liver fibrosis, advanced disease stages, or organ dysfunction

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers

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