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doi:10.3389/fnins.2020.00284 Gurel NZ, Huang M, Wittbrodt MT, et al

This binding triggers a cascade of cellular responses that stimulate the release of growth hormone (GH) from the pituitary gland, which subsequently increases circulating insulin-like growth factor-1 (IGF-1) levels

Although no cases have been reported in humans, some studies have reported a possible association between GLP-1 agonist use and increased risk of thyroid cancer

The principal components believed to be responsible for toxicity are nicotine and benzo[alpha]pyrene through high ROS formation and subsequent OS on the embryo and fetus [284, 285]