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doi: 10.1124/pharmrev.122.000560 128 TuttleKRAgarwalRAlpersCEBakrisGLBrosiusFCKolkhofPet al

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Furthermore, the fact that tracer retention in cortical regions increased with clinical disease severity, as estimated by the Revised ALS Functioning Rating Scale (ALSFRS-R), suggested that OS may be an important factor associated with the development of neurodegeneration in ALS patients [107]

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These inflammatory mediators further damage neurons and disrupt the BBB, allowing peripheral immune cells to infiltrate the CNS (Ramirez et al., 2009)

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Oxidative stress and 4-hydroxy-2-nonenal (4-HNE): implications in the pathogenesis and treatment of aging-related diseases

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