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Jim Schnabel is a freelance writer for Weill Cornell Medicine

After incubation the cerebrovascular fractions were washed three times with PBS and collected in 500 l of lysis buffer

Melanotan II 0.025 mg/kg SC vs placebo

The initial tirzepatide dose in both cohorts was 2.5 mg, which was increased by 2.5 mg every 4 weeks to a maximum final dose of 10.0 mg at week 16 (Cohort 1) or 15.0 mg at week 24 (Cohort 2)