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Vitamins | Treatment summaries | BNF NICE

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

Also, just to note, those with darker skin tones, need to really quite careful with things like salicylic peels as they can cause pigmentation

Methylcobalamin is the most prevalent bioactive coenzyme form of B12 to support detoxification and the central nervous system