Long-Term, Supplemental, One-Carbon MetabolismRelated Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort
History [edit] Descriptions of deficiency effects [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy
For example, if you have a gastrointestinal disorder that affects nutrient absorption, or if you follow a vegan or vegetarian diet, you may be at higher risk of developing a deficiency and may require supplementation
How It Can Cause a Vitamin B12 Deficiency In the stomach, there's a paper-thin layer called the gastric mucosa