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For some it is even controversial if they even do anything at all

In age-related neurological disorders such as AD, the catalytic activity of pyruvate dehydrogenase is suppressed, leading to decreased acetyl-CoA production and impaired TCA cycle energy metabolism (Sang et al

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NADPH produced by G6PD increases the level of NOXs, thereby producing most of the superoxide during the course of heart failure in patients with ischemic cardiomyopathy