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Hara, Y
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Thus, as illustrated in Figure 2, the peptide backbone was modified at position 8 only, where Ala was substituted with Aib, previously shown to be resistant to DPP-IV cleavage and have high GLP-1R affinity ( Figure 2 A systematic test of derivatives from C12 to C20 fatty acids showed that a C18 di-acid together with a Glu-2xOEG linker resulted in the highest albumin affinity combined with GLP-1R potency
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