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Those taking tirzepatide, achieved an additional 18.4% WL from randomisation to 72 weeks compared to those taking placebo who experienced weight regain of 2.5% [48]

However, it did significantly reduce the decrease in motor nerve conduction velocity and paw intraepidermal fiber density observed in diabetic mice through the activation of extracellular signal-regulated kinase (ERK) signaling [81]

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