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At the same time, I tell them about the science of body weight regulation, which is that if somebody loses 10% of their body weight their energy needs actually go down by 15% rather than 10%

Journal of Agricultural and Food Chemistry, 65(2), 358363

However, patients with established type 2 diabetes, significant obesity (BMI 35), cardiovascular risk factors, or previous medication trials should have a provider conversation about whether natural approaches alone meet clinical need

A 2006 Achilles-detachment study by Krivic and colleagues in the same journal applied BPC-157 intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg for 30 days in rats and reported that tendon-to-bone tissue, which did not heal spontaneously in saline controls, recovered with BPC-157 treatment, with directionally improved load-to-failure, stiffness, Young's modulus, and collagen organization at days 121, including in animals where healing had been impaired by 1 mg/kg 6-methylprednisolone though the abstract does not report numeric effect sizes or p-values