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Concomitantly, GLP-1RAs suppress the expression of lipogenic transcription factors and enzymes, including sterol regulatory element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS), resulting in reduced de novo lipogenesis

Reduced food intake often means reduced electrolyte intake, which contributes to fatigue, headaches, and muscle cramps

Smokers Melanosis : Smokers melanosis is a benign condition characterized by brown to black pigmentation of the oral mucosa, typically seen in individuals who smoke tobacco products

Compared with injectable pharmacotherapies, the oral agents orlistat, naltrexone/bupropion and phentermine are less effective for weight loss and lack CVD outcome data (Table 9)