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Additionally, nausea is common initially and can be problematic for IBS patients with heightened gut sensitivity

Treatment is time-limited and subject to response criteria

Metformin, the current first-line treatment in T2DM, has an unclear antidepressant effect [166] despite identified direct mechanisms and pleiotropic effects, including inhibition of angiotensin II and NF-B factor, normalization of gut microbiota, and intestinal permeabilization, and in vivo experimental data [167] supporting its potential benefits

These bags are designed to keep the temperature stable and protect the medication from both heat and light exposure