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At the end of 72 weeks, the change in the ratio of total fat mass to lean mass was 0.24 for tirzepatide versus 0.06 for placebo, indicating a greater improvement with tirzepatide [67]

Clinical and Translational Gastroenterology

The most significant monitoring requirements for patients with acquired hypothalamic obesity starting setmelanotide are: (1) patients who also have secondary adrenal insufficiency a common comorbidity faced a 5% rate of serious acute adrenal insufficiency events in TRANSCEND, versus none on placebo, and require active monitoring during illness or physiological stress

While some of these conditions improved secondary to weight loss, other conditions are impacted directly by GLP-1RAs mechanism of action in the body