Some reasons your body may not be able to get enough B12 from food include: Anemia Gastritis Crohns disease Celiac disease Alcohol use disorder Sjgrens syndrome Weight loss surgery, or surgery that removes part or all of your stomach A vegan or strict vegetarian diet (as B12 is only found in animal products) Medications, such as metformin and drugs used to treat gastroesophageal reflux disease (GERD), indigestion, and stomach ulcers Pregnancy Your doctor could also order a B12 test based on your symptoms
If the liver is overloaded or impaired, or if it lacks antioxidants such as glutathione, vitamin C, and vitamin E, toxins can build up and damage cells, leading to fatigue, digestive distress, skin problems, cognitive issues, and long-term health risks like fatty liver disease or liver damage
Succinic semialdehyde (4-oxobutanoate) acts as a suitable substrate analog` as this molecule only lacks the 3-hydroxy group of MSA (3-hydroxy-4-oxobutanoate) which could be added in silico
With the FDA approval, availability of Wegovy and coverage under many major health insurance plans has skyrocketed