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Depression and the MTHFR Gene Variants: A1298C and C677T A meta-analysis of 26 studies found that the MTHFR C677T variant was associated with an increased risk of depression.[ref] Age and gender may also play a role here

Semaglutide is a synthetic medication engineered to mimic GLP-1's effects while remaining active for approximately 7 days, enabling practical once-weekly dosing