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A review of GLP-1 receptor agonists: evolution and advancement, through the lens of randomised controlled trials

PIONEER 7 was a 52-week open-label trial that compared the efficacy and safety of once-daily oral semaglutide (with flexible-dose adjustment based on prespecified HbA1c and tolerability criteria to approximate treatment individualization in clinical practice) with the DPP-4 inhibitor sitagliptin, as an add-on to existing glucose-lowering medication (one or two oral antidiabetic agents, i.e., metformin, sulphonylureas, SGLT-2 inhibitors or thiazolidinediones), in patients with T2DM

9 Athletes have received multi-year bans for using these peptides

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