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a PDE-5 inhibitor such as sildenafil PT-141 is administered prior to administration of PT-141 , preferably between about 5 minutes and 45 minutes prior to administration of PT-141, more preferably between about 10 and 30 minutes prior, and more preferably still, between about 15 and 20 minutes prior to administration of PT-141

Conversely, IR contributes to reduced dopamine transporter expression coupled with increased excitatory glutamatergic input, elevating extracellular dopamine levels

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Its availability through online sources makes it difficult to ensure quality or safety