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Additionally, GLP-1RAs activate the mitogen-activated protein kinase (MAPK) pathway (Erk1/2, JNK, p38), further supporting osteoblast differentiation and bone formation, with the inhibition of MAPK signaling blocking these protective effects [119]

IV drips can also be used to administer contrast agents for imaging tests or deliver blood transfusions

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She notes that some plans require step therapy (proof that a lower-cost treatment, such as metformin, has been tried first), a recent A1c test, or documentation that the patient has received lifestyle counseling to help manage their diabetes