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Harmonization of postbiotic definitions, dosing strategies, and mechanistic endpoints will be essential to determine clinical relevance beyond preclinical models

CoQ10 is a fat-soluble compound that requires a lipid carrier for optimal absorption

Nausea and gastrointestinal symptoms peak during weeks 6-8, then improve substantially by week 12

After drug treatment for indicated time, 500 nM final concentration of SYTOX Green Nucleic Acid dye was added into each well, cells were further incubated at 37 C for 15 min, and images of at least three randomly chosen fields were captured by an inverted fluorescence microscope (Olympus, Japan)