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When to seek medical advice : Contact your GP or diabetes specialist promptly if you experience: Severe, persistent vomiting or diarrhoea leading to dehydration Severe abdominal pain, particularly if radiating to the back (potential pancreatitis) Signs of hypoglycaemia (if taking insulin or sulphonylureas concurrently) Symptoms of gallbladder problems (pain in the upper right abdomen, fever, yellowing of skin) Any changes in vision (rapid improvement in blood glucose can sometimes worsen diabetic retinopathy) [20] Unexplained persistent nausea beyond the first few weeks If you are planning pregnancy, discuss this with your healthcare provider as GLP-1 RAs are not recommended during pregnancy or breastfeeding

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By combining medication with sustainable lifestyle changes, those struggling with obesity and related conditions may find GLP-1s to be a powerful component of their long-term health journey.

Metabolic adaptation during GLP-1 therapy is less severe than with traditional dieting, which is one of the major advantages of GLP-1 medications