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Additionally, certain genetic markers, such as those in the HLA class II molecules and genes like CARD9 , have been implicated in UC susceptibility, suggesting their involvement in gut immunity, autophagy, and microbial defense

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The approval of XPOVIO was based upon the efficacy and safety in a prespecified subgroup analysis of the 83 patients whose disease was refractory to bortezomib, carfilzomib, lenalidomide, pomalidomide, and daratumumab, as the benefit-risk ratio appeared to be greater in this more heavily pretreated population than in the overall trial population