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In review of GLP-1 receptor agonists surrounding the perioperative period, it was found that there is a variable association with GLP-1 RA use and the findings of RGC with most publications being limited to case reports, retrospective studies, and observational trials (Chang et al

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Exercise and cold exposure induce PGC-1 coactivators, amplifying ERR-dependent gene sets involved in fatty-acid uptake and -oxidation (for example, CPT1, MCAD), OXPHOS subunits, TCA cycle enzymes, and mitochondrial transcription factors (for example, TFAM)

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