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PMID 15012259

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However, when histamine levels become elevated, they can lead to allergic reactions and discomfort, triggering symptoms like: 2 Constant itching Especially around the paws, ears, belly, or tail Skin redness and swelling Sometimes these can lead to sores or hot spots Upset stomach Diarrhea, vomiting, bloating, or excessive gas Breathing troubles Coughing, sneezing, or wheezing Behavior changes Hyperactivity, anxiety, or seeming "on edge." When these symptoms recur frequently and regular treatments dont seem to help, histamine intolerance may be the hidden cause

The authors detail the three key mechanisms through which pramlintide improves glycemic control: suppression of postprandial glucagon secretion, slowing of gastric emptying through vagal mechanisms, and promotion of satiety leading to reduced caloric intake