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Low-Density Lipoprotein Cholesterol and Adverse Cardiovascular Events After Percutaneous Coronary Intervention

However, when IGFBP-1 levels are chronically lowered during prolonged intra-portal hyperinsulinemia (e.g., obesity, Cushings syndrome and glucocorticoid therapy), the accelerator effect of IGFBP-1 is at play to increase serum free IGF-I (35, 40)

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