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The review further noted that MC1R activation may promote anti inflammatory signaling independently of melanin synthesis, suggesting that receptor engagement may produce context dependent outcomes based on ligand structure and cellular environment

This finding warrants careful monitoring in future larger trials, particularly in individuals with pre-existing cardiovascular conditions

Referncias Askarpour M, Hadi A, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E

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