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Data from in vivo study also revealed that a high-fat diet accelerates the proliferation of prostate tumors and increased M2/M1 macrophage ratio and myeloid-derived suppressor cells fraction via interleukin (IL)-6/phospho-signal transducer and activator of transcription 3 (pSTAT3) signaling [43]

T.MirabelliV.HaidukowskiM.LogriecoA

& Young, A

In RCTs comparing GLP-1RA and placebo, insulin doses were reduced before GLP-1RA initiation to avoid hypoglycemia, and close monitoring and insulin adjustments were done periodically