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The FDA issued a warning letter dated March 5, relying on five incidences in which people prescribed the medications had an adverse event associated with the medication such as a stroke, suicidal ideations or even passed away by suicide all of which Novo Nordisk allegedly refused to properly report to the FDA

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The mechanism is thought to involve direct melanocyte stimulation via MC1R, promoting melanocyte proliferation and migration into depigmented areas while UV-B provides the complementary stimulus for melanocyte activation

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