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Oxymetazoline vs Brimonidine for Management of Persistent Facial Erythema Oxymetazoline is an alpha-1a adrenoceptor agonist that causes topical vasoconstriction to lessen erythema associated with rosacea.6 Brimonidine is also a vasoconstrictor, though, it works through selective alpha-2 adrenergic agonism to exert its vasoconstricting effect.7 Brimonidine has a rapid onset within 30 minutes and begins to wear off at 10 to 12 hours at which point some patients report the return of erythema

Peptides, by comparison, remain experimental and should not be considered equivalent to licensed treatments

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