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Benefits include: Downregulation of pro-inflammatory cytokines (e.g., TNF-, IL-6) Calming of mast cell activity Reduced post-injection discomfort and swelling Using KPV continuously throughout the protocol helps balance healing with inflammation control critical for optimal collagen architecture and pain resolution

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De Raedt T, Beert E, Pasmant E, Luscan A, Brems H, Ortonne N, et al

Conversely, when GPX8 is silenced, the histamine-induced release of Ca 2+ from the endoplasmic reticulum to mitochondria and cytoplasm is increased (Yoboue et al., 2017)