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What preclinical research has documented are indirect interactions with several neurochemical systems: Indirect opioid system engagement

Severe thiamin deficiency, which is rare in industrialized nations, except in patients with chronic alcoholism, HIV-AIDS, or gastrointestinal conditions that impair vitamin absorption (23), results in the condition called beriberi, of which there are many forms that involve neurological symptoms

However, AZD3965 is known to deplete the level of intracellular glutathione [28], the thiol-containing tripeptide -L-Glu-L-Cys-Gly (GSH), an antioxidant known to coordinate to transition metal drugs [28, 41, 42]

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