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GHK-based formulations, including nanoparticle conjugates, hydrogels, and clinical derivatives such as TriHex and TriHex 2.0, enhance fibroblast migration, ECM remodeling, collagen and elastin synthesis, and wound closure while providing antimicrobial activity

Contraindications: Lidocaine should not be used if the patient has a known allergy to lidocaine or other amide anesthetics

Data availability Data that support the findings of this study are available upon reasonable request from the corresponding authors

The action on JNK1/2 phosphorylation appears more modest, while ERK1/2 phosphorylation seems largely unaffected, suggesting some selectivity within the MAPK family