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Systemic effects documented in animal studies -- lung tissue protection, neurological effects, joint healing -- are not achievable through topical application

doi: 10.1038/nrneph.2015.162 90

The non-DAC variant (as in this blend) has an extended half-life relative to native GHRH but shorter than CJC-1295 with the Drug Affinity Complex (DAC) modification Ipamorelin a synthetic compound studied as an agonist of the growth hormone secretagogue receptor (GHS-R1a, the ghrelin receptor) a distinct receptor on the same somatotrope cell population, downstream of different intracellular signaling cascades than GHRHR Published research investigates the combinatorial effect of dual-receptor agonism on somatotrope GH-release kinetics in cultured cell models and in-vivo rodent preparations

Examples include avocados, tomatoes, oranges, and spinach