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Those who follow slow-titration protocols generally report fewer days of bothersome symptoms than those advancing doses more rapidly

The cardiovascular safety and efficacy of tirzepatide in adults with T2D has been assessed in a large phase 3 clinical trial (SURPASS-CVOT) (Table 1) [88]

Clinically, the ATTAIN Phase 3 program showed that orforglipron at its highest dose delivered a mean weight loss of 12.4% over 72 weeks, slightly less than the WEGOVY pills 13.6% at 64 weeks, but with a broader, more diverse patient population of over 3,000 participants

Unfortunately, studies involving human test subjects have been of short duration and little is known about the long-term effects of ipamorelin administration