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Additionally, upon coupling with the Y receptor, Gq activates phospholipase C (PLC), a key enzyme that catalyzes the hydrolysis of the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PIP)

Adverse consequences of motility effects of GLP-1RAs In one study, the incidence of retained gastric contents in individuals using a GLP-1RA was 56%, compared with 19% for those not using GLP-1RAs (34), although notably there were more individuals with T2D and obesity in the group treated with GLP-1RAs

and perhaps others

GLP-1 receptor agonists (semaglutide, liraglutide, tirzepatide) do not list infertility as a recognised adverse effect in MHRA-approved product information