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This often includes adopting an anti-inflammatory or low-histamine diet, utilizing mast cell stabilizers (like quercetin or prescription ketotifen), supporting the gut microbiome with targeted probiotics or short-chain fatty acids, and practicing rigorous nervous system regulation techniques

These findings support the safety and potential disease-modifying effects of FUS-mediated BBB opening in early-stage AD, although larger trials are warranted to establish clinical efficacy (Rezai et al., 2024)

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Since AOMs are indicated in combination with lifestyle interventions, all participants received dietary and physical activity counseling, aiming to achieve a 500-kcal deficit per day and 150 minutes of physical activity per week