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While glutathione synthetase deficiency anemia primarily results from genetic factors, other elements such as environmental influences, additional genetic variations, and complex biochemical interactions can impact the severity and manifestations of the disease

Sinha, T., Ikelle, L., Makia, M

These mechanisms make biological sense and support a renoprotective hypothesis

We then limited the dataset to the hospitals with CY 2024 claims data that we used to model the impact of the proposed CY 2026 APC relative payment weights (3,388 hospitals) because we believe it is appropriate to use the same set of hospitals that are being used to calibrate the modeled CY 2026 OPPS