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doi: 10.1371/journal.pgen.1009242

Higher risk from mixing substances: Long-term use alongside alcohol, opioids, benzodiazepines, or other medications puts ongoing strain on the liver, heart, and nervous system

Weight loss continued throughout the entire study period

However, she later had a "horrible experience," possibly due to "this gene, GDF15, which makes you extremely prone to nausea," she said on Howard Stern's SiriusXM show last month."I was like bedridden