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For instance, in study (Teixeira and Rumjanek, 2014), in which the activating effect of CTS was observed, human monocytes were treated with 100 nM of ouabain in vitro , whereas the inhibitory effect was described in vivo on mice with ouabain concentrations reaching 0.56 mg/kg (Jacob et al., 2013), when the maximum concentration in the blood is in the micromolar range

With the identification of key ferroptosis targets (e.g., TRPA1, H3K27 crotonylation), precise interventions using novel small-molecule drugs and biological agents show potential

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