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Secondly, changes in fluid balance and hydration status due to gastrointestinal side effects such as nausea, vomiting, and diarrhoea could potentially contribute to musculoskeletal symptoms, though this remains speculative without robust evidence

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While both GIPRs and GLP-1Rs are present in the CNS, GIPRs are found in regions of the CNS involved in the regulation of food intake, with an expression pattern that does not fully overlap that of GLP-1R [24,25,26]