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Accordingly, long chain fatty acids stimulate GLP-1 secretion mainly through GPR40

Expression of the GIP receptor appears to be more ubiquitous, with Protein Atlas (proteinatlas.org

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As regards the pathogenic mechanisms, the occurrence of an oxidant stress (resulting from an impaired homocysteine metabolism, which modifies the redox status of extra- and intracellular thiols and thus alters the intracellular redox potential) might play a central role in moderate hyperhomocysteinemia-mediated vascular disorders